Biochemist II
Rockville, MD 
Posted Today
Job Description


This job is responsible for manufacturing products using instruments and biochemical processes. The incumbent will utilize techniques such as size exclusion chromatography purification/analysis, oligonucleotide deprotection/conjugation, gel filtration, centrifugation, spectrophotometry, reconstitution, and various assays.


  • Purify protein solutions via FPLC or spin column gel filtration to prepare conjugation/coating solutions or remove free-tag
  • Utilize HPLC to perform size exclusion chromatography analysis on customer samples in order to report percentages of monomer, aggregation, and free-tag
  • Manufacture products by deprotecting oligonucleotide solutions utilizing various chemistries
    • Conjugate oligonucleotide solutions to various proteins
  • Conjugate antibodies with Biotin or SULFO-TAG NHS-Ester in order to produce detection/capture antibodies for use in catalog and custom kits
  • Quantify protein concentrations utilizing techniques such as spectrophotometry or BCA Assay

  • Run assays to quantify biotin/protein ratios or glycerol content in solution

  • Manufacture customer contract materials with specialized procedure and handling requirements

  • Assist the Supervisor in training of new manufacturing personnel

  • Review production records to ensure technicial accuracy and compliance with GDP

  • Maintain preventative maintanence schedules for lab equipment

  • Provide input and execute tasks to improve routine manufacturing processes that provide for better quality and quantity of products

  • Update Standard Operating Procedures or Batch Records as needed

  • Participate in technicial transfer of new processes into the Biochemical Manufacturing team by providing feedback on draft documents and shadowing new production processes during development.

  • Participation in general laboratory maintenance including maintaining laboratory cleanliness, supplies and equipment
    • Prepare, maintain and report raw material or reagent inventories.
    • Participate in year-end physical inventory
  • Specific duties may vary depending upon departmental requirements


  • Bachelor's degree in Biology, Chemistry, Biotechnology, Engineering or related field; or an Associate's degree with equivalent applicable work experience.
  • Two years experience in a manufacturing role utilizing biochemistry techniques


  • A demonstrated aptitude for learning and adhering to standard laboratory techniques and safety precautions
  • Thorough knowledge of scientific fundamentals and analytical background
  • Demonstrate a mechanical aptitude including equipment troubleshooting
  • Excellent oral, written communication and interpersonal skills
    • Effectively communicate issues/problems and results that impact timelines, accuracy and reliability of laboratory data
  • Proficiency in MS Office Suite
  • Ability to follow laboratory safety instructions; ability to use protective equipment.

  • Ability to multi-task and work productively in a demanding manufacturing environment with changing priorities

  • Knowledge of cGMP and/or ISO certification highly preferred

  • Ability to learn additional software applications/tools, as required

  • Knowledge of JDE is highly preferred

  • Knowledge of FPLC or HPLC highly preferred

  • Knowledge of Akta systems highly preferred


  • This position requires the ability to communicate and exchange information, utilize equipment necessary to perform the job, and frequent lifting up to 25 lbs.
  • Up to 80% of the day may be spent at a lab bench and/or in the cleanroom


Standard industrial laboratory environment


Bachelors of Biology (required)

Meso Scale Diagnostics, LLC. provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws.


Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Associate Degree
Required Experience
2+ years
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