Analyst/Manager, Evidence Synthesis and Meta-Analyses (Remote)
Wayne, PA 
Posted Today
Job Description
Analyst/Manager, Evidence Synthesis and Meta-Analyses (Remote) (000022T4)

Xcenda is a premier, full-service consultancy and leading managed markets agency. For more than 2 decades, global biopharmaceutical companies as well as emerging pre-commercialization phase firms have turned to Xcenda for strategic insights, health economics and outcomes research expertise, and reimbursement support. We help manufacturers successfully commercialize innovative medical treatments and technologies in complex and cost-constrained global markets. Our broad, yet strategically connected, array of consulting services supports all phases of the product life cycle.

Under general direction of the Evidence Synthesis and Meta-analyses (ESM) team, the candidate will conduct meta-analyses across global markets, in order to support pharmaceutical, biotech, and device technologies' evidence generation needs. The candidate will also provide methodological and statistical expertise on projects across multiple Xcenda teams focused on evidence generation and health economic initiatives. There may be opportunities for the candidate to participate in projects outside of ESM, including real-world data analytics, economic modeling, health technology assessments, and market access / shaping.


Content Development (~80% of duties):

  • Provide technical support on meta-analysis engagements, including assessing the feasibility of conducting meta-analyses on various literature review findings, developing statistical analysis plans (SAPs), and performing meta-analyses (classical and network), independently and with guidance from the lead biostatistician as needed
  • Develop, conduct or guide templates for data extraction, quality checks, and report development; synthesize and summarize results from meta-analysis feasibility assessments and meta-analyses in plain language for communication to clients (eg, in MS PowerPoint or MS Word documents)
  • Manage large databases for quantitative engagements
  • Conduct standard and network meta-analyses (Bayesian/frequentist approaches) using R and BUGS (WinBUGS, OpenBUGS, or JAGS) or a similar software
  • Contribute to the development of proposals, project budgets, and project timelines
  • Provide support to the project team during systematic literature review design, data extraction, and quality assessment of the included studies

Client Focus (~20% of duties):

  • Participate in calls with current and potential clients (sales calls) to describe proposed or completed meta-analysis projects (methods and results)
  • Serve as a resource for both internal and external clients to aid in the understanding of meta-analysis results
  • Provide technical review of internal team member deliverables prior to delivery to clients
  • Create and execute action plans to advance projects, allocating work and anticipating or identifying and resolving problems
  • Assume responsibility for on-time and on-budget delivery of projects, while maintaining high quality standards

Communication / Collaboration:

  • Assist in the development and sharing of meta-analysis best practices to ensure and maintain the highest quality output consistent with Xcenda's mission and vision
  • Support goals for business unit/service line growth
  • Ensure timeliness, accuracy, and completeness of all services
  • Work with and contribute to project team to complete projects
  • Maintain 70% chargeability

Based on the experience level of the candidate the responsibilities for this role will adjust accordingly. The role could potentially be filled at an Analyst or Manager Director level. Experience may vary based on the level assessed,


An advanced degree in a relevant discipline is the minimum educational requirement, with at least 2 years of practical experience.


  • Proficient with implementing meta-analyses and using statistical software
  • A solid foundational knowledge of and conceptual understanding of biostatistics, especially Bayesian statistics
  • Comprehensive grasp of meta-analytic concepts and methods and the ability to effectively communicate this understanding in both verbal and written form
  • A demonstrated record of scientific publication is desirable, but not required
  • Familiarity with clinical trial design and statistics and their application to the interpretation and presentation of clinical data
  • Experience in other areas of outcomes research (such as observational database research, economic modeling, etc.) is desirable, but not required
  • Ability to organize, prioritize, and maintain high quality work output in a fast-paced dynamic environment while working on multiple projects
  • Demonstrated ability to work within teams
  • Knowledge of the pharmaceutical industry and experience with issues surrounding the marketing of pharmaceutical products in the global marketplace to include the design and use of health economics and outcomes research studies
  • Ability to communicate complex material in presentations and discussions in a straightforward manner
  • Proficiency with Microsoft Office Suite (Word, PowerPoint, Excel) and associated software
  • Travel requirements <10%

Organization: Xcenda

Equal Opportunity Employer/Minority/Female/Disability/Veteran


Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Experience
2+ years
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